D-amino acids and human pathologies

D-serine is involved in:

  • Schizophrenia: hypofunction of NMDAR because of D-Ser decrease;
  • Familial ALS (fALS): R199W DAAO variant is responsible on motoneurons death induced by excitotoxicity;
  • Addiction: decrease in D-Ser level in nucleo accumbens of rat in abstinence following cocaine treatment;
  • Neuropathic pain: inhibition of DAAO (and of hydrogen peroxide production) gives and analgesic effect in neuropatic pain and bone cancer.

D-aspartate is involved in:

  • Increase of testosterone level in male infertility;
  • Brain hormone’s release;
  • Schizophrenia by NMDAR modulation: protective role against sensorimotor-gating deficits;
  • Age-related synaptic plasticity deterioration (in mice).



Authors:

Loredano Pollegioni, Università degli Studi dell'Insubria